Synonym:China Kaempferitrin,China Lespenefril,Lespedin,lespenephril,Kaempferol 3,7-dirhamnoside,Kaempferol 3,7 bisrhamnoside
Chemical Name:
4H-1-Benzopyran-4-one,3,7-bis[(6-deoxy-a-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-
Origin: China
Active Ingredients:Lespedaze
CAS Number:482-38-2
PubChem:5486199
Molecular Formula :C27H30O14
Molecular weight:578.52
Density:1.7 g/cm3
Boiling Point:908.6 degrees Celsius at 760 mmHg
Flash Point:302.8 degrees Celsius
Vapour pressure: 0mmHg at 25 degrees Celsius
Introduction:kaempferitrin is white crystall oid, dissolving in methyl alcohol and ethanol alcohol,and drawing up from chinese thorowax. it's pureness is 60-98%.
Functions:
Kaempferitrin was found to have an acute lowering effect on blood glucose in diabetic rats and to stimulate the glucose uptake percentile, as efficiently as insulin in muscle from normal rats. This compound did not have any effect on glucosuria or on protein synthesis in muscle from normal and diabetic animals. However, the protein synthesis in the kaempferitrin-treated groups was maintained at the same level as the respective controls. Thus, the hypoglycaemic effect and the prompt efficiency of the kaempferitrin in stimulating [U-14C]-2-deoxi-D-glucose uptake in muscle -constitute the first evidence to indicate that the acute effect of this compound on blood glucose lowering may occur as a consequence of the altered intrinsic activity of the glucose transporter (Vmax or glucose transporters translocation?) not involving directly the synthesis of new carriers.
It also promotes renal filtration decreases nitrogenimia, increases the elimination of nitrogen compounds with urine, increases diuresis and improves sodium and potassium elimination.
Indications: The drug is indicated in cases of renal insufficiency and nephropathy caused by hyperammoniemia.